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In the 1980s, a pilot preclinical study on two rat and monkey PD models 16 and two independent clinical cases 17,18 showed that intracerebroventricular (i.c.v.) administration of dopamine improved motor symptoms, but also resulted in tachyphylaxia, possibly owing to dopamine oxidation despite the use of a preservative solution (sodium metabisulfite), precluding the therapeutic development of this concept

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Nausea may increase slightly as the dose doubles, but the B12 component and slow escalation help manage it

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[DOI] [PMC free article] [PubMed] [Google Scholar] 259.Schmitz-Peiffer C

They dont have time to sit there and talk about the patients goals, their sex life, and what they want to do about their 10-pound weight gain, she says